Figure 4: An affinity-matured Alphabody is able to prevent topical inflammation driven by IL-23 in mice.
From: Structural basis of IL-23 antagonism by an Alphabody protein scaffold
The ear thickness of 20 mice, subdivided into four groups (n=5), was measured as a function of time. Control, control group injected with PBS on days 1 to 15 every other day; Groups A–C, mice injected with human IL-23 according to the same scheme; groups B and C, mice that received injections with MB23-PEG on days −1, 0, 3, 6, 9, 12 and 15. Group B mice received intradermal injections of 10 μg of MB23-PEG and group C received intraperitoneal injections of MB23-PEG at 40 mg kg−1. Error bars represent the s.e.m.
