Figure 7: Comparison of binding modes of human IL-23 with antagonists.

Comparison of structures for different IL-23:antagonist complexes: Alphabody:IL-23 complex, adnectin:IL-23 complex (pdb code 3QWR)⁴⁵ and 7G10 antibody:IL-23 complex (PDB code 3D85)²². The complexes are oriented based on structural superpositions against the p19 subunit of human IL-23.