Table 1 Dopamine levels (pmol) in striatal dialysates collected every 15 min in rAAV2-transduced Pink1−/− and Pink1+/+ mice.
From: Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo
Genotype | rAAV2 | n | 0 min | 15 min | 30 min | 45 min | 60 min | 75 min |
|---|---|---|---|---|---|---|---|---|
Pink1 +/+ | GFP | 5 | 0.26±0.06 | 0.26±0.05 | 41.26±4.43 | 2.98±0.38 | 0.13±0.01 | 0.19±0.04 |
Pink1 −/− | GFP | 3 | 0.19±0.03 | 0.22±0.02 | 17.55±3.07 | 2.06±0.18 | 0.19±0.06 | 0.11±0.01 |
Pink1 +/+ | K38A | 4 | 0.22±0.04 | 0.25±0.05 | 42.21±3.89 | 3.53±0.88 | 0.18±0.03 | 0.13±0.05 |
Pink1 −/− | K38A | 4 | 0.33±0.07 | 0.28±0.07 | 42.83±1.87 | 5.65±0.78 | 0.19±0.06 | 0.13±0.02 |
Pink1 +/+ | Fis1 | 4 | 0.22±0.03 | 0.24±0.02 | 29.45±2.40 | 2.62±0.33 | 0.19±0.03 | 0.15±0.03 |
Pink1 −/− | Fis1 | 3 | 0.19±0.04 | 0.14±0.04 | 19.46±1.33 | 1.65±0.14 | 0.18±0.05 | 0.13±0.03 |
