Table 2 Dopamine levels (pmol) in striatal dialysates collected every 15 min in mdivi-1-treated-Pink1−/− and Pink1+/+ mice.
From: Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo
Genotype | Treatment | n | 0 min | 15 min | 30 min | 45 min | 60 min | 75 min |
|---|---|---|---|---|---|---|---|---|
Pink1 +/+ | Vehicle | 5 | 0.47±0.07 | 0.40±0.09 | 36.11±3.68 | 5.58±1.52 | 0.87±0.19 | 0.49±0.09 |
Pink1 −/− | Vehicle | 4 | 0.44±0.08 | 0.53±0.14 | 15.24±3.44 | 1.39±0.31 | 0.36±0.06 | 0.30±0.05 |
Pink1 −/− | Mdivi-1 | 4 | 0.53±0.10 | 0.47±0.07 | 38.97±6.53 | 4.99±0.80 | 1.19±0.21 | 0.62±0.10 |
