Table 3 Dopamine levels (pmol) in striatal dialysates collected every 15 min in MPTP pre-lesioned mice with Drp1 inhibition.
From: Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo
Treatment | Drp1 inhibition | n | 0 min | 15 min | 30 min | 45 min | 60 min | 75 min |
|---|---|---|---|---|---|---|---|---|
a | ||||||||
Saline | GFP | 5 | 1.27±0.22 | 1.17±0.39 | 95.35±5.67 | 5.62±2.07 | 1.08±0.39 | 1.04±0.37 |
MPTP | GFP | 4 | 2.39±0.06 | 2.24±0.19 | 36.04±4.83 | 4.32±0.55 | 2.08±0.06 | 1.98±0.02 |
Saline | K38A | 5 | 2.01±0.07 | 2.01±0.01 | 98.59±8.96 | 6.38±2.65 | 2.11±0.06 | 1.92±0.02 |
MPTP | K38A | 4 | 2.08±0.06 | 2.12±0.07 | 58.17±5.83 | 4.51±0.71 | 2.05±0.04 | 2.04±0.04 |
b | ||||||||
Saline | Vehicle | 5 | 2.71±0.23 | 2.98±0.17 | 66.25±3.15 | 13.28±2.28 | 3.36±0.36 | 2.59±0.10 |
Saline | Mdivi-1 | 4 | 2.80±0.21 | 2.68±0.07 | 60.01±13.6 | 8.28±2.21 | 2.76±0.15 | 2.48±0.07 |
MPTP | Vehicle | 5 | 2.88±0.17 | 2.78±0.16 | 20.10±3.46 | 6.01±0.99 | 2.79±0.19 | 2.41±0.06 |
MPTP | Mdivi-1 | 5 | 3.73±0.36 | 3.40±0.55 | 39.45±7.11 | 10.95±1.74 | 2.88±0.08 | 2.81±0.14 |
