Figure 2: Host TLR4 activation promotes tumour metastasis. | Nature Communications

Figure 2: Host TLR4 activation promotes tumour metastasis.

From: Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box1 protein

Figure 2

(a) WT and TLR4−/− mice were injected with LPS i.p., followed by B16F10 infusion i.v. 6 h later. Fourteen days later, the lungs were isolated and representative photographs are shown. The number of metastatic foci is shown in the right panel (n=5 per group). (b) WT and TLR4−/− mice were injected with TAK-242 i.p., followed by B16F10 infusion i.v. 1 h later. Fourteen days later, the lungs were isolated and representative photographs were shown. The number of metastatic foci was shown in the right panel (n=5 per group). *P<0.05; **P<0.01; calculated by Mann–Whitney U-test. Data are representative of three independent experiments.

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