Figure 5: Representative in vivo images of the cortical vasculature seen through CLEAR device. | Nature Communications

Figure 5: Representative in vivo images of the cortical vasculature seen through CLEAR device.

From: Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

Figure 5

(a) Bright-field image of CLEAR device implanted on the cerebral cortex of a mouse beneath a cranial window. (b) Fluorescence image of same device shown in a. Mouse was given an intravenous injection of fluorescein isothiocyanate–dextran to fluorescently label the vasculature. (c,d) Higher magnification bright-field and fluorescence images of same device shown in a and b, respectively. (e,f) Bright-field and fluorescence images of standard rat-sized micro-ECoG arrays with platinum electrode sites, respectively. Scale bars, 500 μm (a,b), 250 μm (c,d), 750 μm (e,f). In vivo vasculature imaging was repeated in three rats, each with a CLEAR and platinum microECoG array. Images were representative of presented and previously published data7,50.

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