Table 1 Discovery and replication of newly discovered protective variants at 6q25 related to breast cancer risk in Latinas.
6q25 Region | Alleles* | OR | 95% CI | P value | MAF † |
|---|---|---|---|---|---|
Discovery (1,497 cases/3,213 controls) | |||||
rs140068132 | A/G | 0.60 | 0.49–0.72 | 3 × 10−7 | 9% |
rs147157845 | C/A | 0.59 | 0.48–0.72 | 1 × 10−7 | 9% |
Replication Mexicans (977 cases/1,158 controls) | |||||
rs140068132 | 0.63 | 0.53–0.75 | 3 × 10−7 | 15% | |
rs147157845 | 0.66 | 0.55–0.78 | 3 × 10−6 | 15% | |
Replication Colombians (546 cases/440 controls) | |||||
rs140068132 | 0.54 | 0.41–0.71 | 1 × 10−5 | 10% | |
rs147157845 | 0.55 | 0.42–0.72 | 2 × 10−5 | 10% | |
Replication WHI Hispanics (120 cases/3,373 controls) | |||||
rs140068132 | 0.61 | 0.31–1.22 | 0.16 | 7% | |
rs147157845 | 0.60 | 0.30–1.19 | 0.15 | 7% | |
Meta-analysis (3,140 cases/8,184 controls) | |||||
rs140068132 | 0.60 | 0.53–0.67 | 9 × 10−18 | ||
rs147157845 | 0.61 | 0.54–0.68 | 2 × 10−16 | ||
