Figure 1: CCI induced a transient depolarizing shift of EGABA and reduction of GGABA in primary sensory neurons.
From: Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction
Mechanical (a) and thermal hyperalgesia (b) induced by CCI surgery on the left sciatic nerve. n=7 mice (two-way analysis of variance; P<0.0001 for both). (c) Representative traces of GABA-activated currents recorded in DRG neurons during gramicidin perforated patch at various holding potential mV. (d) Current–voltage relationship for GABA-activated response from large (left) and small (right) neurons. (e) Bar graph showing the time course of the changes in EGABA. (f) Bar graph showing the time course of the changes in conductance of GABAAR. The number of neurons recorded is indicated in parentheses in each panel. *P<0.05; **P<0.01; unpaired t-test. Error bars indicate s.e.m.
