Figure 2: Exosome sensitivities and expression levels of annotated transcript biotypes.
From: Nuclear stability and transcriptional directionality separate functionally distinct RNA species
(a) Densities of exosome sensitivity of RNAs emanating in the major direction (defined as most dominating in the control CAGE library) of considered DHSs, broken up by GENCODEv17 TSS annotations associated with the corresponding DHSs. Sensitivity was defined as the relative fraction of measured RNA abundance reduced by the exosome (the fraction of hRRP40 CAGE expression level not detected with control CAGE, see Methods). (b) Same as a, but assessing RNAs on the opposite (minor) strand. (c) Expression levels from DHSs, associated with the indicated RNA biotypes, assessed as ranked CAGE expression levels in control HeLa cells of RNAs emanating from major strands at DHSs broken up by annotation as above.
