Figure 3: KrasC118S/C118S mice have no overt phenotypes.
From: Decreased tumorigenesis in mice with a Kras point mutation at C118
(a) Photograph of a Kras+/+ (+/+) and KrasC118S/C118S (C118S/C118S) adult mouse at 3 weeks of age. (b,c) Mean body weight±s.e.m. of ([cirf ]) Kras+/+ versus (▴) KrasC118S/C118S (b) male (n=6 versus 5) and (c) female mice (n=4 versus 5) from 8 to 25 weeks of age. (d) Mean heart to body weight ratio±s.e.m. of 4-week-old Kras+/+ (+/+) versus KrasC118S/C118S (C118S/C118S) mice (n=4). (e) Kaplan–Meier survival curves of Kras+/+ (black line, n=8) versus KrasC118S/C118S (red line, n=10) mice. P value was determined by multivariate analysis of variance test (b,c), two-tailed unpaired Student’s t-test (d) and long-rank test (e).
