Figure 4: Decreased urethane-induced lung tumorigenesis in mice with a KrasC118S allele.
From: Decreased tumorigenesis in mice with a Kras point mutation at C118
(a) Visible lesions (arrows) of lungs from one Kras+/+ (+/+) and one KrasC118S/C118S (C118S/C118S) mouse 8 months after treatment with urethane. (b) Number of visible surface tumour lesions per mouse, (c) diameter of each visible surface tumour lesion and, (d) tumour burden, as defined by the sum of the diameters of all visible surface tumour lesions per mouse, from Kras+/+ (+/+, 27 mice, 285 visible surface tumours), Kras+/C118S (+/C118S, 25 mice, 132 visible surface tumours) and KrasC118S/C118S (C118S/C118S, 25 mice, 121 visible surface tumours) mice 8 months after treatment with urethane. Bars: mean±s.e.m. NS: non-significant (P>0.05), **P<0.01 and ***P<0.001, as determined using one-way analysis of variance plus post-hoc Bonferroni’s multiple comparison test.
