Figure 6: Oncogenic Q61 mutations occur preferentially on the native Kras allele.
From: Decreased tumorigenesis in mice with a Kras point mutation at C118
Pie chart of the number and percent of Q61R/L oncogenic mutations found in the native versus the C118S Kras allele, as determined by RT–PCR amplification and sequencing of Kras mRNA isolated from 32 lung lesions from 15 Kras+/C118S mice 8 months after treatment with urethane. P value was determined using the χ2 test to compare the difference between the observed and the expected frequency.
