Figure 2: Synergistic upregulation of pro-inflammatory cytokines on c-IgG-TLR ligand co-stimulation does not differ between HD and RA patients. | Nature Communications

Figure 2: Synergistic upregulation of pro-inflammatory cytokines on c-IgG-TLR ligand co-stimulation does not differ between HD and RA patients.

From: Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages

Figure 2

(a) M2 macrophages derived from monocytes of HD (n=20) or RA patients (n=9) were stimulated with Pam3CSK4 or Pam3CSK4 combined with c-IgG. Each pair of dots represents one donor. *P≪0.05, **P≪0.01, ***P≪0.001; NS, not significant, Kruskal Wallis test. (b) HD M2 macrophages were stimulated with Pam3CSK4 combined with HD c-IgG or c-IgG from RA patients. Data (mean+s.e.m.) are representative of four experiments with different donors. (a,b) After 24 h, cytokine levels were determined by ELISA. Experiments were performed in triplicate.

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