Figure 4: c-IgG-TLR ligand co-stimulation of M2 macrophages promotes Th17 responses. | Nature Communications

Figure 4: c-IgG-TLR ligand co-stimulation of M2 macrophages promotes Th17 responses.

From: Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages

Figure 4

M2 macrophages were stimulated with Pam3CSK4, c-IgG or a combination and co-cultured with allogeneic CD4+ T cells. After T cell outgrowth, resting T cells were restimulated. (a) After 24 h, cytokine levels were determined by ELISA, mean+s.e.m. Experiments were performed in triplicate. (b) T cells were analysed for intracellular IL-17 and IFN-γ by flow cytometry. (a,b) Data are representative of three experiments with different donors.

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