Figure 2: Quantification of the loss of regulatory elements upon 3′ UTR shortening.
From: Global 3′ UTR shortening has a limited effect on protein abundance in proliferating T cells
Influence of 3′ UTR shortening on miRNA (a) and RBP (b) target sites. The x axis represents the z-score of the loss of binding sites obtained by comparing the observed loss of target sites with what would be expected from random permutations of target sites across the set of alternative 3′ UTRs. A negative z-score indicates that the loss in binding sites is greater than if sites were placed randomly in alternative regions of 3′ UTRs. RBPs with a stabilizing effect on their transcript targets as assigned in Ray et al.32 are marked in blue, whereas RBPs with a destabilizing effect are marked in red. The inset shows z-scores obtained for representative PWMs of RBPs with stabilizing and destabilizing effects (P-value obtained from a Wilcoxon rank sum test).
