Figure 3: Evaluation of changes in mRNA levels in naive and activated murine T cells with respect to changes in poly(A) site usage.
From: Global 3′ UTR shortening has a limited effect on protein abundance in proliferating T cells
(a) Comparison of fold-changes in mRNA abundance for genes with a single or multiple poly(A) sites (PAS; P-values obtained from a one-sided t-test). (b) Correlation between changes in mRNA abundance and changes in poly(A) site usage. The centre of mass of the cloud of points is at a positive x-value, reflecting the noted increase in proximal poly(A) site use in dividing cells. (c) Contour plot of the log-likelihood of the data as a function of the mean and standard deviation of the log ratio of decay rates (z) of the short and long 3′ UTR isoforms. The colour gradient ranging from red to white describes the log likelihood obtained under the model, with white values showing the better fit. The box marks the 95% posterior probability interval of the parameters (μz, σz).
