Figure 4: Landscape of key genetic alterations in gastric cancers.

(a) The patient samples are shown on the x-axis. On the y-axis (top to bottom panel), the coding region mutation rate, top 12 significantly mutated genes, selected COSMIC and recurrent mutated genes, recurrent copy-number alterations (gains and deletions), clinical information, presence of TpT mutational signature, clonality, ploidy and purity are provided. The number of patients with an observed alteration type or types in given in the second column in the lower panel marked as ‘#Samples’. Different mutation and genomic alteration types are shown in different colours. Additional information is added as follows. Genes in the copy-number alterations have been marked with ‘M’ if they carried a non-synonymous mutation; ‘X’ did not show overexpression of protein by immunohistochemistry; ‘?’ for ambiguous results. The rows related to clonality, ploidy and purity have been coloured for values above the average for ease of visualization. (b) Somatic mutations in the axon guidance pathway genes. The mutated genes are grouped as being involved in the following signalling cascades: Ephrins, SLIT, Semaphorins and Netrins (KEGG pathway: Axon Guidance).