Figure 4: Organ distribution of dye-functionalised NP. | Nature Communications

Figure 4: Organ distribution of dye-functionalised NP.

From: Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles

Figure 4

MSOT images of non-functionalised NP or NP functionalised with DY-635 with ICG as cargo or functionalised with DY-704. The dye-moiety (in case of DY-704) or ICG cargo (in the case of DY-635 or non-functionalised NP) were used for imaging by MSOT; NP are shown in green irrespective of the dye moiety. All NP were identified in the circulation (V=retroperitoneal vessels) and showed uptake by spleen (S) indicating phagocytic clearance; however, only DY-635 functionalised NP showed significant uptake by the liver (L), whereas DY-704 functionalised NP had an increased accumulation in the kidneys (K) (scale bars 5 mm)

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