Figure 3: Mutations in TP53 and their impact on ICC patient survival.
From: Mutational landscape of intrahepatic cholangiocarcinoma
(a) Sites of amino-acid changes in p53 due to mutations in TP53. Conservation of these sites was evaluated by the multiple sequence alignment of TP53 orthologues in man (Homo sapiens), gorilla (Gorilla gorilla gorilla), mouse (Mus musculus), rat (Rattus norvegicus), cat (Felis catus), chicken (Gallus gallus), rainbow trout (Oncorhynchus mykiss) and frog (Xenopus leavis). (b) Comparison of survival of ICC patients with TP53 mutations (With P53) and without TP53 mutations (Without P53). Survival analysis was done using SPSS.
