Figure 4: Significantly altered pathways in ICC.

Mutation frequencies are expressed as the percentage under the gene names. In this figure, in most cases, only genes mutated more than one patient are shown in the pathway. (a) Genes mutated in the Ras/PI3K signalling pathway, comparison of survival of ICC patients with KRAS mutations (with KRAS) and without KRAS mutations (without KRAS); (b) p53/cell cycle signalling pathway; (c) TGF-β/SMAD signalling pathway; (d) epigenetic regulators; (e) Oxidative phosphorylation. Survival analysis was done using SPSS. The colour intensity of the boxes represents the number of ICC patients who carry mutations in the gene.