Table 2 Significantly mutated genes in the 102 ICC patients.
From: Mutational landscape of intrahepatic cholangiocarcinoma
Gene | P -value FCPT * | Cases † with mutations | Non-silent mutations | Synonymous mutations | d N /d S |
|---|---|---|---|---|---|
TP53 | 0.00E+00 | 39 | 42 | 1 | 42:1 |
KRAS | 0.00E+00 | 17 | 17 | 0 | 17:0 |
MT-ND4 | 9.78E-12 | 9 | 9 | 1 | 9:1 |
MT-ND5 | 5.48E-10 | 9 | 9 | 2 | 9:2 |
IDH1 | 2.54E-06 | 5 | 5 | 0 | 5:0 |
MT-CO1 | 6.01E-06 | 6 | 7 | 3 | 7:3 |
PTEN | 3.34E-05 | 6 | 7 | 0 | 7:0 |
ARID1A | 1.81E-04 | 7 | 8 | 1 | 8:1 |
MT-ND6 | 4.27E-04 | 4 | 4 | 2 | 4:2 |
LCE1F | 6.31E-04 | 3 | 3 | 0 | 3:0 |
MT-CO3 | 6.50E-04 | 4 | 5 | 0 | 5:0 |
RB1 | 1.09E-03 | 5 | 5 | 0 | 5:0 |
GOLGA6L2 | 1.17E-03 | 5 | 8 | 11 | 8:11 |
EPHA4 | 7.28E-03 | 4 | 4 | 0 | 4:0 |
EPPK1 | 7.43E-03 | 6 | 6 | 1 | 6:1 |
SMAD4 | 9.55E-03 | 4 | 4 | 0 | 4:0 |
CDH18 | 1.27E-02 | 3 | 5 | 0 | 5:0 |
MT-ND1 | 1.49E-02 | 3 | 3 | 2 | 3:2 |
ALB | 1.81E-02 | 3 | 3 | 1 | 3:1 |
FAM182B | 2.00E-02 | 2 | 3 | 3 | 3:3 |
ECE2 | 2.17E-02 | 4 | 4 | 0 | 4:0 |
TDRD1 | 3.29E-02 | 4 | 5 | 0 | 5:0 |
GRIA1 | 3.53E-02 | 3 | 4 | 2 | 4:2 |
CNTNAP5 | 3.55E-02 | 3 | 4 | 2 | 4:2 |
FYN | 4.47E-02 | 3 | 3 | 0 | 3:0 |
