Table 3 IFNL4 haplotype combination and associated clearance phenotypes.
Diplotype* | N | Proportion of patients | IFNλ4 production | SVR | % SVR | CHI | SC | % SC | ||
|---|---|---|---|---|---|---|---|---|---|---|
70P | 70S | − | + | |||||||
TT G/TT G | 277 | 0.398 | − | − | 39 | 156 | 0.800 | 195 | 82 | 0.296 |
TT G/ΔG G | 231 | 0.332 | + | − | 111 | 105 | 0.486 | 216 | 15 | 0.065 |
TT G/ΔG A | 110 | 0.158 | − | + | 30 | 64 | 0.681 | 94 | 16 | 0.146 |
ΔG G/ΔG G | 39 | 0.056 | + | − | 17 | 17 | 0.500 | 34 | 5 | 0.128 |
ΔG A/ΔG G | 29 | 0.042 | + | + | 19 | 8 | 0.296 | 27 | 2 | 0.069 |
TT G/TT A | 5 | 0.007 | − | − | 0 | 4 | 1.000 | 4 | 1 | 0.200 |
ΔG A /ΔG A | 4 | 0.006 | − | + | 0 | 3 | 1.000 | 3 | 1 | 0.250 |
TT A/TT A | 1 | 0.001 | − | − | 0 | 1 | NA | 1 | 0 | NA |
