Figure 6: Cryo-ET provides new insights into the structural basis of human RSPH1 PCD.
From: Cryo-electron tomography reveals ciliary defects underlying human RSPH1 primary ciliary dyskinesia
Schematic representation of the comparison between the native 3D structures of respiratory cilia from normal controls (including RSPH1−/+ carrier) and PCD patient (RSPH1−/−). Our cryo-ET analysis revealed both unprecedented structural details of normal respiratory cilia (left column) and the previously unknown, yet consistently present primary RS defects and the heterogeneous secondary CPC defects in the RSPH1-mutant cilia (right column). At/Bt, A- and B tubules.
