Figure 7: The mechanistic models of G9a-dependent, gene-specific regulation of transcription. | Nature Communications

Figure 7: The mechanistic models of G9a-dependent, gene-specific regulation of transcription.

From: A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing

Figure 7

(a) c-Myc is a dual-functional transcription factor dependent upon either an acetyl-lysine or methyl-lysine-enriched environment when chronically active G9a promotes its transcriptional activity to repress select genes. (b) Chronically active G9a selectively recruits defined protein complexes into the chromatin of pro-inflammatory genes for their silencing during ET.

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