Figure 3: MORC1 regulates DNA methylation in a stage- and locus-specific manner.
From: MORC1 represses transposable elements in the mouse male germline
(a) Total CG and CA methylation levels in Morc1tg/+ and Morc1tg/tg sorted germ cells. Three to four replicates per genotype and time point were analysed; mean and s.e. are indicated. (b) Number of hypermethylated and hypomethylated DMRs, calculated using pooled BS-seq data at each time point. (c) Boxplots of DNA methylation levels at E16.5, P2.5 and P10.5 are shown for the set of regions that were computed as hypomethylated at P2.5 in Morc1tg/tg germ cells. (d) Box plots of levels of DNA methylation levels in germ cells at E16.5, P2.5 and P10.5 are shown for the set of regions that were computed as hypomethylated at P10.5 in Morc1tg/tg. For c,d, each DMR constitutes one point in each box plot. Red lines, median; edges of boxes, 75th (top) and 25th (bottom) percentiles; whiskers, minimum and maximum points within 1.5 × the interquartile range; red dots, outliers.
