Figure 1: Genome-wide analysis of the DNA-damage transcriptome of HCT116 cells. | Nature Communications

Figure 1: Genome-wide analysis of the DNA-damage transcriptome of HCT116 cells.

From: Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature

Figure 1

(a) Biotype distribution of all the transcripts identified by RNA-seq analysis generated from HCT116 cells untreated or treated with DNA damage annotated relatively to ENCODE v19. (b) Biotype distribution of the differentially expressed transcripts following DNA-damage treatment with 5-FU for 12 h. (c) Percentage of the transcripts identified by RNA-seq with H3K4me3, H3K4me1 or/and H3K27ac marks at the 5′ position of the defined transcript structures. (d) Schematic representation of the chromosomal location of the CDKN1A gene locus, RNA expression detected by RNA-seq of DNA-damage-treated cells and, H3K4me3 and H3K4me1 levels of HCT116 untreated cells and CDKN1A transcript isoforms as assembled by Cufflinks. (e) Subtypes’ distribution of the lncRNAs found differentially expressed following 5-FU treatment.

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