Figure 6: Tert rescues serum parameters associated with heart failure.
(a) Serum urea concentration as a measure of renal and heart functionality was determined in the indicated groups. n, number of mice. Statistical analysis: two-sided Student’s t-test, P-values are shown. (b) Individual heatmaps (from blue—lowest, to red—highest value) of serum concentration of the indicated biomarkers comparing three conditions: MI+AAV9-empty (n=8), MI+AAV9-Tert (n=8), sham (no virus) (n=4). n, number of mice. The indicated numbers within squares represent true values in pg μl−1 serum. (c) A selection of serum biomarkers with implications in heart biology that show significant changes between MI and sham animals as determined in multi-analyte profiling represented as box and whiskers plot. Statistical analysis: Mann–Whitney U-test, P-values are shown. (d) Relative mRNA expression level (qRT–PCR) of ANP in non-infarcted mice (>2years). Mean values with s.e.m are represented. n, number of mice. Statistical analysis: two-sided Student’s t-test, P-values are shown.
