Figure 4: Inactivating gene fusions of NF1 in lung cancer. | Nature Communications

Figure 4: Inactivating gene fusions of NF1 in lung cancer.

From: Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes

Figure 4

(a) NF1 protein schematic and the observed fusion breaks (red arrows) in the index cases are displayed on top. Recurrent NF1 fusions with partners (GOSR1, PSMD11, NLK, DRG2 antisense and MYO15A antisense) resulted in loss of the NF1 gene as illustrated by the corresponding fusion protein structure below. Index samples are indicated in parenthesis and the numbers over the protein schematic indicate total amino acids. Red # symbol indicate protein truncation due to out-of-frame ORFs from fusion transcript analysis. (b) UCSC browser view of genomic location of NF1 gene and its fusion partners (top). Schematic representation of various NF1 rearrangements on chromosome 17 identified in lung cancer (bottom).

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