Figure 5: Conservation of epigenetic marks in constrained genes. | Nature Communications

Figure 5: Conservation of epigenetic marks in constrained genes.

From: Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression

Figure 5

(a) Normalized histone modification profiles 1 kb around transcription start site (TSS) for H3K4me3 and H3K27ac, and around the TTS for H3K36me3 in constrained and unconstrained genes. (b) The difference in normalized average histone modification signals 1 kb around TSS (|Δlog Signal|) in constrained and unconstrained genes. (c) The cumulative distribution of the number of TF ChIP-seq peaks in promoter regions of human constrained and unconstrained genes. (d) Principal component analysis of ChIP-seq measured binding strength of TFs in constrained and unconstrained genes.

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