Figure 1: Simultaneous lin-35 Rb and fzr-1 loss of function eliminates cyd-1 and cdk-4 requirement.
From: Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells
(a) Model for cell cycle entry in C. elegans illustrating more than one critical function of CYD-1/CDK-4. (b) Quantification of total progeny numbers (bars) for animals of the indicated genotypes. (c) Quantification of the number of intestinal nuclei for the indicated genotypes. (d) Quantification of the number of descendants of the P2–P10 ventral cord precursor cells for the indicated genotypes. The candidate-null alleles used are cyd-1(he112), cdk-4(gv3) and the lin-35 alleles n745 and n2239. Total broods were counted of at least two animals of each genotype and total cell numbers in the indicated tissues of at least ten animals of each genotype. Graphs show mean±s.e.m., each dot (c,d) represents a single animal.
