Figure 2: Antibiotics increase mosquito susceptibility to infection by Plasmodium ingested in the same blood meal.
From: Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
(a–d) Oocyst counts after PS-treated or control (‘C’) blood meal on P. berghei-infected mice (a), naive mice, followed with a 2nd blood meal on untreated P. berghei-infected mice 3 days later (b), P. falciparum gametocyte cultures (c) and naturally infected P. falciparum blood samples (d). Medians and oocyst distributions of representative experiments are shown. (e) Forest plots showing the effect of PS treatment on Plasmodium infection intensities in each replicate as determined by GLMM analysis. The variation of the fixed effect estimate in each (squares) and all (diamonds) replicates are shown (±95% confidence interval, glmmADMB). Within each chart, the square size is proportional to the mosquito number. From left to right, charts show the effect on P. berghei - 2nd BF, P. falciparum—lab and P. falciparum—field respectively. Mosquitoes (n=18–205) per experiment and per condition (average 86 (±8 s.e.m.)).
