Figure 5: Cross-phenotype meta-analysis revealing functional clusters of genes and proteins indicating patterns of shared disease mechanisms across autoimmune diseases.
(a) Fifty SNPs with evidence of association to more than one autoimmune disease (Pcpma<0.01) are clustered by association with disease. (b) For each cluster and disease pair, a cumulative association statistic was calculated using Fisher’s omnibus test to combine P values. The varying pattern of disease association for each cluster suggests each group represents a distinct co-morbid mechanism. (c) Proteins coded within a 100-Mb window centred on each SNP within each cluster are depicted in protein–protein interaction maps. Three of the five clusters have significant protein inter-connectivity (permuted P<0.05).
