Figure 6: MBH oleic acid and hepatic vagal innervation. | Nature Communications

Figure 6: MBH oleic acid and hepatic vagal innervation.

From: A fatty acid-dependent hypothalamic–DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins

Figure 6

(a) Experimental protocol: immediately preceding vascular catheterization, rats underwent a hepatic vagotomy (HepVx) or sham operation (ShamVx). MBH preinfusions of vehicle or oleic acid were commenced at t=−10 min. (b) TG concentrations, (c) rates of appearance of VLDL-TG, (d) glucose concentrations and (e) FFA concentrations in plasma in sham-operated rats with MBH infusion of vehicle (white open squares, n=6) or oleic acid (black squares, n=7) or vagotomized rats with vehicle (grey circles, n=4) or oleic acid (grey triangles, n=6). *P<0.05 versus ShamVx+vehicle. †P<0.02, ††P<0.008 versus HepVx+vehicle. ‡P<0.02, ‡‡P<0.008 versus HepVx+oleic acid. Data are presented as mean+s.e.m. Statistical significance determined by Dunnett’s post hoc test after analysis of variance (ANOVA). For measurements over time, repeated measures ANOVA was used followed by Duncan’s post hoc test.

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