Figure 7: Firing categories of iPSC-derived MNs are predicted by peak Na+ and K+ currents. | Nature Communications

Figure 7: Firing categories of iPSC-derived MNs are predicted by peak Na+ and K+ currents.

From: Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

Figure 7

(a) Relationship between peak Na+ and K+ currents and action potential firing category were determined using multinomial logistic regressions in control (n=448), TARDBP (n=230) and C9ORF72 (n=176) iPSC-derived MNs at 3–6 weeks post plating. Values in parentheses denote the proportion, as a percentage, of iPSC-derived MNs exhibiting each firing category. (b) Predicted probability of each firing category calculated over a range of peak Na+ currents. (c) Predicted probability of each firing category calculated over a range of peak K+ currents.

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