Figure 2: Increased vulnerability to atrial but not ventricular arrhythmias in exercised animals. | Nature Communications

Figure 2: Increased vulnerability to atrial but not ventricular arrhythmias in exercised animals.

From: Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα

Figure 2

Vulnerability to atrial or ventricular arrhythmias was assessed in vivo using an intracardiac catheter placed in the right ventricle. Representative intracardiac bipolar electrograms showing induction of atrial arrhythmias (a) as well as surface electrogram recordings in the lead II configuration showing induction of ventricular tachyarrhythmias (VT; b) from sedentary, swimming and treadmill exercised mice. The percentage of animals with sustained (>10 s) atrial (c) but not VT (d) is increased significantly by exercise. (e) A typical representative AF event initiated in isolated (denervated) atria by rapid stimulation recorded using field recording (top) and optical mapping images of atria loaded with a voltage sensitive dye during sinus rhythm (SR) and during AF (bottom). Note the disorganized wave propagation during an AF episode. Red arrows indicate the wave-front pathway. (f) Percentage of isolated atria from each group showing sustained AF episodes (>10 s). The n value for each group is indicated on bar graphs and present number of mice. χ2-test *P<0.05.

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