Figure 8: Reduced inflammation with TNF inhibition.

(a) Representative Mac-3-stained atrial sections for macrophages/monocytes (shown by red arrows) showing prevention of macrophage/monocyte count increases in exercised etanercept treated and exercised TNFα−/− mice compared with untreated exercised mice summarized in (b). The n value shown on bar graphs and present number of mice used. Data presented as mean±s.e.m. **P<0.05 when exercised untreated is compared with exercised+Etn or exercised TNFα−/− using one-way ANOVA with Dunnett’smultiple comparison test. Scale bar, 100 μm.