Table 3 Three independent associations to HLA class I genes in the UK Immunochip data set.

From: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Gene

Position

Allele/residue

Omnibus P value

A1/A2

P-value*

Minor allele freq.

Odds ratio*

CI*

      

Cases

Controls

  

HLA-C

—

*0602

5.85 × 10−52

P/A

—

0.19

0.09

2.34

2.02:2.71

HLA-B

67

Cysteine

5.6 × 10−13

P/A

6.53 × 10−14

0.15

0.12

1.62

1.43:1.84

  

Phenylalanine

 

P/A

7.44 × 10−6

0.23

0.25

1.29

1.15:1.44

  

Methionine

 

P/A

7.89 × 10−5

0.1

0.05

1.45

1.20:1.72

  

Tyrosine

 

P/A

0.79

0.13

0.17

1.02

0.89:1.26

  

Serine

 

P/A

ref

0.39

0.42

ref

ref

HLA-A

—

*0201

3.31 × 10−13

P/A

—

0.34

0.28

1.39

1.27:1.52

  1. A, absent; A1, allele 1; A2, allele 2; CI, confidence interval; freq, frequency; HLA, human leukocyte antigen; P, present.
  2. *Calculated in a regression including HLA-C*0602, HLA-B amino acid position 67 and HLA-A*0201.
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