Figure 1: SAN cell rate response to ISO is impaired by Ru360 or DN-MCU and rescued by ATP.
From: The mitochondrial uniporter controls fight or flight heart rate increases
(a–c) Example action potential (AP) tracings recorded under basal (left) and ISO-stimulated (right) conditions from freshly isolated SAN cells. The horizontal line marks 0 mV. Scale bars are 100 ms horizontal and 20 mV vertical. (d) Summary dose–response data for SAN cell AP rate responses to ISO. (e–g) Example AP tracings recorded under basal (left) and ISO-stimulated (right) conditions from cultured SAN cells. The horizontal line marks 0 mV. Scale bars are the same as in (a–c). (h) Summary dose–response data for cultured SAN cell AP rate responses to ISO. (i,j) Percentage rate increases over baseline after ISO in isolated SAN cells. (i) Freshly isolated SAN cells (data calculated from d). (j) Cultured SAN cells (data calculated from h). *P<0.05, **P<0.01, ***P<0.001, one-way analysis of variance, n=10–15 per group in d, n=5–9 per group in h. Error bars indicate s.e.m.
