Table 1 Top 10 downregulated genes.
From: Origins of multicellular evolvability in snowflake yeast
Gene | Fold change | FDR-adjusted P value | Function |
|---|---|---|---|
SCW11 | −16.5 | 6.22·10−12 | Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p. |
CTS1 | −13.6 | 2.86·10−43 | Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p. |
DSE1 | −9.7 | 1.21·10−12 | Daughter cell-specific protein, may regulate crosstalk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall. |
AMN1 | −8.8 | 5.55·10−9 | Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucin10-rich repeat motifs; expression is induced by the Mitotic Exit Network. |
DSE2 | −6 | 7.10·10−20 | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP. |
IZH4 | −5.3 | 1.34·10−7 | Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism. |
YNL277W-A | −4.9 | 0.013919 | Putative protein of unknown function. |
YFR057W | −4.7 | 0.040354 | Putative protein of unknown function. |
DSE4 | −4.3 | 6.32·10−08 | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother. |
SUN4 | −3.3 | 3.92·10−05 | Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family. |
