Figure 10: Model depicting how the Ser177 phosphorylation of Pdlim5 attenuates lamellipodia formation.
From: Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5
(a) Under normal conditions, Arhgef6 recruited to the IPP complex at the cell periphery activates Rac1, contributing to efficient lamellipodia formation. (b) Once AMPK activity is augmented, Ser177 of Pdlim5 is phosphorylated, displacing Arhgef6 from the IPP complex and causing attenuation of lamellipodia. Boxed areas at the cell periphery are expanded, representing views from the top (left) and from the side (right); see text for explanation. ILK, integrin-linked kinase; PINCH, particularly interesting new cysteine-histidine-rich protein; Pdlim5, PDZ and LIM domain 5; WAVE, Wiskott–Aldrich Syndrome protein family verprolin homologous.
