Figure 3: Effects of binding of glycan-dependent bNAbs.
From: Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env
Butterfly plots show the exchange profiles of SOSIP.664 trimers either unliganded or as complexes with (a) PG9 Fab, (b) PGT123 Fab and (c) 2G12 IgG. The differences are mapped onto the trimer crystal structure (d–f), as described in Fig. 2. As a reference, the approximate positions of the Fabs are shown as transparent surfaces (modelled from PDB accession codes 3NGB, 3U4E and 4NCO)70, while glycans known to be relevant to the epitopes are shown as magenta sticks2,28,30. No structure is yet available for the PGT123 trimer complex; hence, PGT122 is shown instead, as its epitope is very similar (PDB: 4NCO)2,10
