Figure 2: Integrative annotation of the 8q24 risk locus.
From: Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
(a) Topologically associating domain (TAD) borders at 8q24.21 consistently observed in LS174T, LoVo and Colo205 cell lines, as determined by domain calling on the directionality index (DIX). Positive and negative values indicate preferential downstream and upstream interactivity of a bin, respectively. (b) Statistical significance of the CRC association across the region; the darker the colour the stronger the association. The top associated SNP in the region is rs6983267. (c) Statistically significant looping interactions. Test bins in green, interactor bins in red. (d) Regulatory elements in HCT116.
