Figure 8: Model of pre-B cell synapse formation. | Nature Communications

Figure 8: Model of pre-B cell synapse formation.

From: Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions

Figure 8

(a) GAL1 secreted by stromal cells is bound to LacNAc epitopes presented by stromal cell integrins and receptors. (b) When a pre-BII cell contacts the stromal cell, pre-BII cell integrins interact with their stromal cell ligands and GAL1 can bind Pre-BCRs and glycosylated receptors. (c) On binding to the pre-BCRs, GAL1 undergoes a decreased affinity for LacNAc epitopes thus weakening its anchoring to both cell glycans. GAL1 is then available for interaction to better ligands found on pre-BII cell relocalizing integrins. (d) The molecular link established by GAL1 between relocalizing pre-BII cell integrins and pre-BCRs drives these latters at the contact zone between the two cells. Relocalization of the pre-BCRs leads to cell signalling necessary for pre-BII cell differenciation and proliferation.

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