Figure 7: Summary of Treg, Tconv and DC dynamics.
From: Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming
(a) Cellular choreography illustrating cell dynamics and the role of CTLA using cell shapes rendered from 2P images (Tregs, green; Tconv, red; DCs, blue). Panels represent steady-state conditions (top left); inflammation (LPS DC; top right); T-cell priming in three phases (middle); Tregs interacting with clusters during phase II under normal priming conditions (labelled ITC for isotype control, bottom left) and in the presence of CTLA4-blocking antibody (labelled αCTLA4, bottom right). (b) Chart of relative surface expression by Tconv cells during T-cell priming. CD4 density refers to the local concentration of antigen-specific T cells near antigen-presenting DCs during phase II. (c) Colour-coded diagram of measured contact durations among Tregs and Tconvs (top panel), and among T cells and DCs (bottom panel). Each change in contact duration (different colours) represents a significant difference of at least P<0.05.
