Figure 4: PAXX works in both the same and parallel DNA repair pathways with XLF. | Nature Communications

Figure 4: PAXX works in both the same and parallel DNA repair pathways with XLF.

From: Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

Figure 4

(a) Sensitivity curves for PAXX−/− DT40 cells complemented by wild-type, F201A or Nmut variants of human PAXX in G1/S phase. Cells were arrested in G1/S phase before IR treatment. Mutant sites in Nmut are indicated in Supplementary Fig. 1a. (Sensitivity assays to analyse genetic interactions of PAXX with XRCC4, Lig4 (b) and XLF (d) in asynchronous DT40 cells. Survival curves were measured using MTS assay. The mean and s.d. from three independent experiments are shown. (c) A cartoon showing potential genetic relationships of PAXX with XRCC4, Lig4 and XLF under different treatment conditions.

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