Figure 1: Association between molecular and clinicopathological features of paediatric adrenocortical tumours. | Nature Communications

Figure 1: Association between molecular and clinicopathological features of paediatric adrenocortical tumours.

From: Genomic landscape of paediatric adrenocortical tumours

Figure 1

(a) Upper panel: clinicopathological features of 19 patients in the WGS cohort. Centre panel: genetic alterations, including mutational status of TP53 (R337H identified by asterisk), ATRX and CTNNB1; telomere length; number of SVs; BMR; chromothripsis and kataegis. Und: undetermined malignancy. Lower panel: RNA expression of selected genes involved in chromosomal segregation and cell cycle control. Three distinct tumour groups (labelled below) emerged from this analysis. Control: normal adrenocortical tissue. (b) Kaplan–Meier probability of event-free survival (exact log-rank test) of paediatric ACT patients in group 1 versus others.

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