Table 3 Associations of the two top SNPs with PA based on various definitions in 2,197 discovery samples of European ancestry.

PA definitions	Cases	rs7192*				rs9275596^†
		OR^‡	95% CI^‡	P _GEE ^‡	P _MQLS ^§	OR^‡	95% CI ^‡	P _GEE ^‡	P _MQLS ^§
CR, plus psIgE ≥0.1 kU l⁻¹ or SPT ≥3 mm	316	1.7	1.4–2.1	1.7 × 10⁻⁷	5.5 × 10⁻⁸	1.7	1.4–2.1	9.6 × 10⁻⁸	6.8 × 10⁻¹⁰
CR in 2 h, plus psIgE ≥0.1 kU l⁻¹ or SPT ≥3 mm	286	1.8	1.4–2.2	1.5 × 10⁻⁷	6.7 × 10⁻⁸	1.8	1.4–2.2	1.8 × 10⁻⁷	1.9 × 10⁻⁹
CR in 2 h, plus psIgE ≥0.35 kU l⁻¹ or SPT ≥3 mm	278	1.8	1.4–2.2	2.0 × 10⁻⁷	1.0 × 10⁻⁷	1.8	1.4–2.2	1.8 × 10⁻⁷	2.5 × 10⁻⁹
CR in 2 h, plus psIgE ≥0.35 kU l⁻¹ or SPT ≥5 mm	276	1.7	1.4–2.2	4.2 × 10⁻⁷	3.6 × 10⁻⁷	1.7	1.4–2.2	3.0 × 10⁻⁷	6.7 × 10⁻⁹
CR in 2 h, plus psIgE ≥15 kU l⁻¹ or SPT ≥8 mm	216	1.8	1.4–2.3	7.5 × 10⁻⁷	1.4 × 10⁻⁶	1.8	1.4–2.3	7.0 × 10⁻⁷	8.9 × 10⁻⁸
CR in 2 h, plus psIgE ≥57 kU l⁻¹ or SPT ≥8 mm	187	1.8	1.4–2.3	4.2 × 10⁻⁶	2.3 × 10⁻⁵	1.8	1.4–2.2	9.2 × 10⁻⁶	4.2 × 10⁻⁶

CI, confidence interval; CR, clinical allergic reaction to peanut ingestion; GEE, generalized estimating equation; MQLS, modified quasi-likelihood score; OR, odds ratio; PA, peanut allergy; psIgE, peanut-specific IgE; SNP, single-nucleotide polymorphism; SPT, skin prick test.
^*Using the minor allele (T allele) as the effective allele and the major allele (G allele) as the reference allele.
^†Using the minor allele (C allele) as the effective allele and the major allele (T allele) as the reference allele.
^‡The GEE model was applied to estimate the effect size of each SNP (additive genetic model) on the risk of PA in PA cases versus 733 non-PA children, with adjustment for age and gender, and controlling for within-family relationships.
^§The MQLS test was applied to estimate the P-value by comparing PA cases, 144 non-allergic, non-sensitized normal controls and 1,737 controls of uncertain phenotype.

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