Figure 3: Most dsDMRs with decreasing DNA methylation level between 6 and 24 hpf are developmental enhancers. | Nature Communications

Figure 3: Most dsDMRs with decreasing DNA methylation level between 6 and 24 hpf are developmental enhancers.

From: Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos

Figure 3

(a) Averaged vertebrate PhastCons scores of 10 kb regions centred on dsDMRs were plotted. (b) A weighted Venn diagram of dsDMRs overlapping with different histone modification peaks from 24 hpf embryo. (c) Histone modification signature of dsDMRs. Average ChIP-seq RPKM values from 24 hpf embryos were plotted over 10 kb regions centred on the dsDMRs. (d) Heat maps of ChIP-seq signal over 10 kb regions centred on individual dsDMRs. (e) Enriched GO terms and their binomial P-values from analysing dsDMRs using GREAT42. The top 20 GO terms were displayed here and the full list of GO terms enriched was in Supplementary Fig. 11a. (f) Expression profiles of genes associated with dsDMRs from GO enrichment analysis across different developmental stages.

Back to article page