Figure 3: β3-AR agonism activates BAT and increases browning of WAT in E3L.CETP mice.
From: Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Slides of intBAT of β3-AR agonist CL316243- and vehicle-treated E3L.CETP mice were (a) stained with haematoxylin–eosin (HE) or (c) immunohistochemically stained for UCP1, and representative pictures are shown. Scale bar, 200 μm (for × 15 original magnification) and 20 μm (for × 100 original magnification). (b) Lipid droplet-positive area, (d) UCP1 content per area and (e) UCP1 content of the total fat pad were quantified. Slides of epidydimal WAT (epiWAT) were stained with (f) HE and (g) immunohistochemically stained for UCP1, and representative pictures are shown. Scale bar, 100 μm. Values are means±s.e.m. (n=8 per group). *P<0.05, **P<0.01 (unpaired two-tailed Student’s t-test).
